The review, which is the most exhaustive of its kind to date, was led by Esther Myers, specialist in systematic research reviews at the International Life Sciences Institute. Myers and her team, who are presenting the findings this week at the Experimental Biology conference in Chicago, looked at how different levels of caffeine affected people in the short and long term, taking special care to look for any adverse health effects in the cardiovascular, musculoskeletal, reproductive, or behavioral areas.
What might happen if you drink more than that in a day? Myers’ team found evidence of links to depression and dysphoria (general dissatisfaction with life), as well as anxiety, hypertension, and even higher numbers of sperm with DNA damage in men. Having that fifth cup of coffee for the day on occasion isn’t completely unsafe if you’re healthy, says Myers, but it’s best not to make a habit of it. And if only one cup of coffee already has too much caffeine for you, maybe go with tea instead.